Spinphox

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August undefined, 2024

WebFeb 13, 2012 · There are numerous reports on the synthesis of 2,3-dihydrobenzofurans, but newefficient and highlyantioselective methods that permit access to the corresponding reduced analogues are highly desirable. were successfully hydrogen-ated to the corresponding tetrahydroquinolines, tetrahydro-quinoxalines, and indolines with more … WebApr 29, 2024 · Initially, the model reaction of cyclic N-sulfonyl aldimines 1a and phenylboronic acid 2a was performed in the presence of Pd(TFA) 2 (5 mol%, TFA trifluoroacetate) and four representative spiro phosphine–oxazoline ligands L1-L4 (7.5 mol%) in unpurified TFE at 40 °C (Table 1, entries 1–4).We were pleased to find that all the …

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WebThe utility of SpinPHOX ligand was exemplified by the reduction of α,α-bisbenzylidene derivatives to furnish spiro-acetal compounds in high enantioselectivity (Scheme 11). Substituents on the phenol ring did not influence the reaction. Iridium (III) species generated by the reduction of the iridium complex played a role as a WebOct 10, 2014 · Herein, SpinPhox/IrI catalysts have been demonstrated to be highly enantioselective in the asymmetric hydrogenation of the C C bonds in the exocyclic … blyth memorial arena

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WebAlfa Chemistry offers 1,5-cyclooctadiene{(4S)-(-)-2-[(5R)-6-(diphenylphosphino)spiro[4.4]nona-1.6-dien-1-yl]-4,5-dihydro-4-phenyloxazole}iridium(I) tetrakis[3,5-bis ... WebJul 2, 2024 · Enantioselective hydrogenation of a broad spectrum of N-, O-, and S-containing aromatic benzoheterocycles or nonaromatic unsaturated heterocycles has been realized by using an Ir/SpinPHOX (SpinPHOX=spiro[4,4]-1,6-nonadiene-based phosphine-oxazoline) complex as the catalyst, affording an array of the corresponding chiral benzoheterocycles … WebSpinPhox/Ir-I catalysts have been demonstrated to be highly enantioselective in the asymmetric hydrogenation of the CC bonds in the exocyclic,-unsaturated cyclic carbonyls, … blyth memorial hall

Highly enantioselective asymmetric hydrogenation of (E)-β,β ...

Catalytic asymmetric synthesis of aromatic spiroketals by …

WebSpinPHOX/Ir catalyst had generality especially toward not only 5~6 membered α-benzylidene ketones but also lactones or lactams (Scheme 10, Equation 1).…” Section : Methods mentioning confidence: 99% cleveland ga swap shopWebJun 5, 2024 · An Ir/spiro[4,4]-1,6-nonadiene-based phosphine-oxazoline ligand (SpinPHOX) complex-catalyzed double asymmetric hydrogenation of 3,6-dialkylidene-1,4 … blyth merinos

"WebOct 10, 2014 · Herein, SpinPhox/IrI catalysts have been demonstrated to be highly enantioselective in the asymmetric hydrogenation of the C C bonds in the exocyclic α,β‐unsaturated cyclic carbonyls, including a broad range of α‐alkylidene lactams, unsaturated cyclic ketones, and lactones. It is noteworthy that the procedure can be … " - Spinphox

Spinphox

Highly enantioselective hydrogenation of α-aryl-β-substituted …

Web张翱，男，博士、中国科学院上海药物所研究员、博士生导师、国家杰出青年基金获得者、中国科学院“百人计划”择优支持和上海“浦江人才计划”优秀奖获得者。现为上海科技大学生命科学与技术学院特聘教授。主要从事化学生物学及药物化学研究，尤其是针对神经精神性与肿瘤两大疑难疾病 ... WebTake it for a spin: SpinPhox/Ir I complexes are highly efficient and versatile in the enantioselective hydrogenation of a broad spectrum of exocyclic α,β-unsaturated …

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Web× Close. The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. WebFeb 10, 2014 · Herein, SpinPhox/Ir(I) catalysts have been demonstrated to be highly enantioselective in the asymmetric hydrogenation of the C C bonds in the exocyclic α,β …

WebThe Ir(i) complexes of chiral spiro phosphino–oxazoline ligands (SpinPhox) have demonstrated good to excellent enantioselectivity in the asymmetric hydrogenation (AH) … WebThe first asymmetric hydrogenation of 3-ylidenephthalides has been developed using the Ir I complex of a spiro[4,4]-1,6-nonadiene-based phosphine-oxazoline ligand (SpinPHOX) as …

WebAug 20, 2024 · An Ir/SpinPHOX complex catalyzed double asymmetric hydrogenation of 3,6-dialkylidene-1,4-dimethylpiperazine-2,5-dione has been developed, providing an efficient … WebJan 12, 2006 · SpinPhox/Iridium(I)-Catalyzed Asymmetric Hydrogenation of Cyclic α-Alkylidene Carbonyl Compounds. Angewandte Chemie International Edition 2014, 53 (10.1002/anie.v53.7) , 1978-1982. DOI: 10.1002/anie.201309521. Eugenia Marqués-López, Raquel P. Herrera. Organocatalysis in Total Synthesis.

WebSep 9, 2010 · A new type of chiral bisoxazoline ligands 1 based on spiro[4,4]-1,6-nonadiene backbone was easily prepared in six steps from racemic spiro[4,4]-nonane-1,6-dione, with the Pd-catalyzed coupling of the enol triflates with CO and amino alcohols as the key steps for the construction of the oxazoline moiety. The structure of the ligand (R,S,S)-1b was …

WebJul 15, 2014 · An Ir/SpinPHOX complex catalyzed double asymmetric hydrogenation of 3,6-dialkylidene-1,4-dimethylpiperazine-2,5-dione has been developed, providing an efficient … cleveland ga sushiWebSep 24, 2009 · In the present communication, we report our preliminary results on the use of Ir(I) complexes of a novel class of spiro[4,4]-1,6-nonadiene-based phosphine – oxazoline ligands (SpinPHOX, 2) 9 in the catalytic asymmetric hydrogenation of a variety of α-aryl-β-substitued acrylic acids (1), leading to the production of a series of biologically ... cleveland ga taxiWebThe enantioselective hydrogenation of a series of challenging substrates, α-aryl-β-substituted acrylic acids, was realized with high efficiency and enantioselectivity (up to 96%) under the catalysis of Ir(i) complex of Spiro-based P,N ligand, SpinPHOX. Selective Catalysis for Organic Synthesis cleveland gate guisboroughWeb– Electronic Supplementary Information (ESI) – Highly enantioselective hydrogenation of α-aryl-β-substituted acrylic acids catalyzed by Ir-SpinPHOX Yi Zhang,a,b Zhaobin Han,b Fuying Li,a Kuiling Ding,b,* Ao Zhanga,* a Synthetic Organic & Medicinal Chemistry Laboratory, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 … cleveland ga tax assessorWebApr 19, 2012 · An Ir/SpinPHOX complex catalyzed double asymmetric hydrogenation of 3,6-dialkylidene-1,4-dimethylpiperazine-2,5-dione has been developed, providing an efficient and practical access to a wide ... blyth metals ltdWebJan 1, 1999 · SpinPhox/iridium(I)-catalyzed asymmetric hydrogenation of cyclic α-alkylidene carbonyl compounds. Angewandte Chemie - International Edition 2014 Journal article DOI: 10.1002/anie.201309521 EID: 2-s2.0-84893619843. Contributors ... blyth metals dinningtonWebThe Ir(i) complexes of chiral spiro phosphino–oxazoline ligands (SpinPhox) have demonstrated good to excellent enantioselectivity in the asymmetric hydrogenation (AH) of a variety of (E)-β,β-disubstituted α,β-unsaturated N-methoxy-N-methylamides, affording the corresponding optically active Weinreb amides wi cleveland ga tax records