WebMechanistic investigations revealed that integrin α6β4 stimulated the activation of ATM, p53, and 53BP1, which required the integrin β4 signaling domain. Genetic manipulation of gene expression demonstrated that mutant p53 cooperated with integrin α6β4 for cisplatin sensitivity and was necessary for downstream phosphorylation of 53BP1 and ... WebHKDC1 overexpression conferred chemoresistance to cisplatin, oxaliplatin, and 5‐fluorouracil (5‐Fu) onto GC cells. Furthermore, nuclear factor kappa‐B (NF‐κB) inhibitor PS‐341 could attenuate tumorigenesis, metastasis, and drug resistance ability induced by HKDC1 overexpression in GC cells. ... ATM is a protein kinase that plays a ...
Caspase-mediated cleavage of ATM during cisplatin-induced
WebWhether it's raining, snowing, sleeting, or hailing, our live precipitation map can help you prepare and stay dry. WebJul 1, 2024 · In this method, aqueous cis/trans-platin is reacted with excess thiourea on gentle heating so that cisplatin produces deep yellow water soluble solution of [Pt (Th) 4 ]Cl 2 (Th = thiourea) while transplatin forms white water insoluble trans- [Pt (NH 3) 2 (Th) 2 ]Cl 2 and hence they can be distinguished only by visual identification. porch avengers infinity war
Silence of URI in gastric cancer cells promotes cisplatin-induced …
WebApr 8, 2024 · Cisplatin-resistant cancer cells own higher malignance and exhibited increased metastatic ability, but the mechanism is not clear. In this study, we … WebApr 1, 2024 · Triple-negative tumor cells, a malignant subtype of breast cancer, lack a biologically targeted therapy. Given its DNA repair inhibiting properties, caffeine has been shown to enhance the effectiveness of specific tumor chemotherapies. In this work, we have investigated the effects of caffeine, cisplatin, and a combination of the two as potential … WebOct 13, 2024 · Cisplatin is actively transported into cells via the plasma membrane sodium pump, copper transporter, and organic cation transporters [ 5 ]. Reduced expression of genes encoding the protein... porch awning for campervan